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Together and especially if two or three show up at once with no other clear explanation they're worth paying attention to

Approximately 60% of samples had alterations in EGFR, KRAS, ALK, MET, HER2, RET or ROS1

Several clinical trials have demonstrated the FAEs efficacy in this role (6, 8)

These viral vectors, which express antigens or cytokines locally, can restore tumor suppressor functions or enhance antitumor immune responses

Overall, 17% of patients developed an acute hypersensitivity reaction (18% in the 15-minute infusion group

Notably, one of the few methods that can endogenously reactivate tumor suppressor genes in a locus-specific manner is targeting lncRNAs [379]